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Removing the toxic enantiomer from crop products with selective gene editing - Nature Plants
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Gossypol is a defense compound in cotton; both axially chiral gossypol enantiomers confer pest resistance, but (−)-gossypol is toxic for humans. We identified a gene (GhDIR5) that selectively promotes (−)-gossypol synthesis. GhDIR5 knockout enabled the production of (−)-gossypol-depleted cottonseeds without affecting pest resistance.
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