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Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation - Nature Immunology

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Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation - Nature Immunology

Unlike other nucleotide oligomerization domain-like receptors, Nlrp10 lacks a canonical leucine-rich repeat domain, suggesting that it is incapable of signal sensing and inflammasome formation. Here we show that mouse Nlrp10 is expressed in distal colonic intestinal epithelial cells (IECs) and modulated by the intestinal microbiome.

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Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation - Nature Immunology

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Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation - Nature Immunology

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