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Mitochondrial damage activates the NLRP10 inflammasome - Nature Immunology

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Mitochondrial damage activates the NLRP10 inflammasome - Nature Immunology

Upon detecting pathogens or cell stress, several NOD-like receptors (NLRs) form inflammasome complexes with the adapter ASC and caspase-1, inducing gasdermin D (GSDMD)-dependent cell death and maturation and release of IL-1β and IL-18. The triggers and activation mechanisms of several inflammasome-forming sensors are not well understood. Here we show that mitochondrial damage activates the NLRP10 inflammasome, leading to ASC speck formation and caspase-1-dependent cytokine release.

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Mitochondrial damage activates the NLRP10 inflammasome - Nature Immunology

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Mitochondrial damage activates the NLRP10 inflammasome - Nature Immunology

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