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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes - Nature Cell Biology

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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes - Nature Cell Biology

The pancreatic islets are composed of discrete hormone-producing cells that orchestrate systemic glucose homeostasis. Here we identify subsets of beta cells using a single-cell transcriptomic approach. One subset of beta cells marked by high CD63 expression is enriched for the expression of mitochondrial metabolism genes and exhibits higher mitochondrial respiration compared with CD63lo beta cells.

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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes - Nature Cell Biology

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A beta cell subset with enhanced insulin secretion and glucose metabolism is reduced in type 2 diabetes - Nature Cell Biology

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