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Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy - Nature Neuroscience

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Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy - Nature Neuroscience

In the brains of patients with epilepsy, apolipoprotein E-mediated lipid transfer from hyperactive neurons to astrocytes results in lipid metabolism reprogramming and formation of lipid-accumulated reactive astrocytes. These astrocytes exacerbate abnormal discharges of neighboring neurons and, in mice, aggravate seizure symptoms, leading to disease progression.

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Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy - Nature Neuroscience

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Abnormal lipid metabolism shapes astrocyte reactivity in patients with epilepsy - Nature Neuroscience

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