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Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice - Nature Neuroscience

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Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice - Nature Neuroscience

Myelin degeneration occurs in neurodegenerative diseases and aging. In these conditions, resident oligodendrocyte progenitor cells (OPCs) differentiate into oligodendrocytes that carry out myelin repair. To investigate the cellular dynamics underlying these events, we developed a noninflammatory demyelination model that combines intravital two-photon imaging with a single-cell ablation technique called two-photon apoptotic targeted ablation (2Phatal).

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Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice - Nature Neuroscience

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Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice - Nature Neuroscience

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