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Generation of functional oocytes from male mice in vitro - Nature

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Generation of functional oocytes from male mice in vitro - Nature

Sex chromosome disorders severely compromise gametogenesis in both males and females. In oogenesis, the presence of an additional Y chromosome or the loss of an X chromosome disturbs the robust production of oocytes1–5. Here we efficiently converted the XY chromosome set to XX without an additional Y chromosome in mouse pluripotent stem (PS) cells. In addition, this chromosomal alteration successfully eradicated trisomy 16, a model of Down's syndrome, in PS cells.

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Generation of functional oocytes from male mice in vitro - Nature

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Generation of functional oocytes from male mice in vitro - Nature

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