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Whole-genome doubling drives oncogenic loss of chromatin segregation - Nature

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Whole-genome doubling drives oncogenic loss of chromatin segregation - Nature

Whole-genome doubling (WGD) is a recurrent event in human cancers and it promotes chromosomal instability and acquisition of aneuploidies1–8. However, the three-dimensional organization of chromatin in WGD cells and its contribution to oncogenic phenotypes are currently unknown. Here we show that in p53-deficient cells, WGD induces loss of chromatin segregation (LCS).

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Whole-genome doubling drives oncogenic loss of chromatin segregation - Nature

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Whole-genome doubling drives oncogenic loss of chromatin segregation - Nature

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