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cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans - Nature Structural & Molecular Biology

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cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans - Nature Structural & Molecular Biology

The metazoan cGAMP-activated cGAS–STING innate immunity pathway is triggered in response to genomic instability and DNA damage, thereby providing host defense against microbial pathogens. This pathway also impacts on autophagy, cellular senescence and antitumor immunity, while its overactivation triggers autoimmune and inflammatory diseases.

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cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans - Nature Structural & Molecular Biology

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cGAMP-activated cGAS–STING signaling: its bacterial origins and evolutionary adaptation by metazoans - Nature Structural & Molecular Biology

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