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Oligomer nanoparticle release from a biodegradable plastic triggers acute gut inflammation - Nature Nanotechnology
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Biodegradable polylactic acid (PLA) microplastics are shown to undergo enzymatic hydrolysis by lipases found in the human gut to generate PLA oligomers, which self-aggregate to form nanoplastic particles. The oligomers and their nanoparticles bioaccumulated in multiple organs of a mouse model and caused acute intestinal inflammation.
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