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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness - Cell Research

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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness - Cell Research

Tonic signaling of chimeric antigen receptor (CAR), i.e., the spontaneous CAR activation in the absence of tumor antigen stimulation, is considered to be a pivotal event controlling CAR-T efficacy. However, the molecular mechanism underlying the spontaneous CAR signals remains elusive. Here, we unveil that positively charged patches (PCPs) on the surface of the CAR antigen-binding domain mediate CAR clustering and result in CAR tonic signaling.

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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness - Cell Research

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Tuning charge density of chimeric antigen receptor optimizes tonic signaling and CAR-T cell fitness - Cell Research

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