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Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression - Cell Research

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Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression - Cell Research

A well-established role of cyclic GMP-AMP synthase (cGAS) is the recognition of cytosolic DNA, which is linked to the activation of host defense programs against pathogens via stimulator of interferon genes (STING)-dependent innate immune response. Recent advance has also revealed that cGAS may be involved in several noninfectious contexts by localizing to subcellular compartments other than the cytosol.

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Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression - Cell Research

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Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression - Cell Research

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