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Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy - Nature

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Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy - Nature

Extracellular deposition of amyloid-β as neuritic plaques and intracellular accumulation of hyperphosphorylated, aggregated tau as neurofibrillary tangles are two of the characteristic hallmarks of Alzheimer's disease1,2. The regional progression of brain atrophy in Alzheimer's disease highly correlates with tau accumulation but not amyloid deposition3–5, and the mechanisms of tau-mediated neurodegeneration remain elusive.

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cells neurodegeneration tauopathy microglia health cell biology biology microbiology

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Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy - Nature

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Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy - Nature

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