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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis - Nature Biotechnology

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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis - Nature Biotechnology

The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the paucity of human-relevant models for target discovery and compound screening. Here we use human fetal hepatocyte organoids to model the first stage of NAFLD, steatosis, representing three different triggers: free fatty acid loading, interindividual genetic variability (PNPLA3 I148M) and monogenic lipid disorders (APOB and MTTP mutations).

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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis - Nature Biotechnology

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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis - Nature Biotechnology

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