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Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury - Cell Death Discovery

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Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury - Cell Death Discovery

Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired survival pathways contribute to liver injury caused by hepatotoxins. We investigated the role of hepatic autophagy, a cellular survival pathway, in cholestatic liver injury driven by a hepatotoxin. Here we demonstrate that hepatotoxin contained DDC diet impaired autophagic flux, resulting in the accumulation of p62-Ub-intrahyaline bodies (IHBs) but not the Mallory Denk-Bodies (MDBs).

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Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury - Cell Death Discovery

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Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury - Cell Death Discovery

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