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Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP - Signal Transduction and Targeted Therapy

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Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP - Signal Transduction and Targeted Therapy

Dysfunctions of ATP-binding cassette, subfamily D, member 1 (ABCD1) cause X-linked adrenoleukodystrophy, a rare neurodegenerative disease that affects all human tissues. Residing in the peroxisome membrane, ABCD1 plays a role in the translocation of very long-chain fatty acids for their β-oxidation. Here, the six cryo-electron microscopy structures of ABCD1 in four distinct conformational states were presented.

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Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP - Signal Transduction and Targeted Therapy

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Structural insights into substrate recognition and translocation of human peroxisomal ABC transporter ALDP - Signal Transduction and Targeted Therapy

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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