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A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis - Communications Biology

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A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis - Communications Biology

Light chain (AL) amyloidosis is a debilitating disease in which mutant antibody light chains (LC), secreted by aberrant plasma cell clones, misfold and form insoluble fibrils, which can be deposited in various organs. In the majority of cases, the fibrillar deposits consist of LC variable domains (VL) containing destabilizing mutations compared to their germline counterparts. This is also true for the patient LC FOR005.

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A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis - Communications Biology

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A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis - Communications Biology

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