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Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition - Communications Biology

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Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition - Communications Biology

CD47 recognized by its macrophage receptor SIRPα serves as a “don't eat-me” signal protecting viable cells from phagocytosis. How this is abrogated by apoptosis-induced changes in the plasma membrane, concomitantly with exposure of phosphatidylserine and calreticulin “eat-me“ signals, is not well understood.

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Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition - Communications Biology

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Nanoscale imaging of CD47 informs how plasma membrane modifications shape apoptotic cell recognition - Communications Biology

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