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Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration - npj Regenerative Medicine

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Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration - npj Regenerative Medicine

The irreversible loss of cardiomyocytes in the adult heart following cardiac injury leads to adverse cardiac remodeling and ventricular dysfunction. However, the role of B cells in cardiomyocyte proliferation and heart regeneration has not been clarified. Here, we found that the neonatal mice with B cell depletion showed markedly reduced cardiomyocyte proliferation, leading to cardiac dysfunction, fibrosis scar formation, and the complete failure of heart regeneration after apical resection.

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Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration - npj Regenerative Medicine

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Murine neonatal cardiac B cells promote cardiomyocyte proliferation and heart regeneration - npj Regenerative Medicine

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