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Sequence determinant of small RNA production by DICER - Nature

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Sequence determinant of small RNA production by DICER - Nature

RNA silencing relies on specific and efficient processing of double-stranded RNA by Dicer, which yields microRNAs (miRNAs) and small interfering RNAs (siRNAs)1,2. However, our current knowledge of the specificity of Dicer is limited to the secondary structures of its substrates: a double-stranded RNA of approximately 22 base pairs with a 2-nucleotide 3′ overhang and a terminal loop3–11.

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Sequence determinant of small RNA production by DICER - Nature

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Sequence determinant of small RNA production by DICER - Nature

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