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Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins - Nature Chemical Biology

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Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins - Nature Chemical Biology

Single-strand RNA (ssRNA) Fiersviridae phages cause host lysis with a product of single gene (sgl for single-gene lysis; product Sgl) that induces autolysis. Many different Sgls have been discovered, but the molecular targets of only a few have been identified. In this study, we used a high-throughput genetic screen to uncover genome-wide host suppressors of diverse Sgls.

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Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins - Nature Chemical Biology

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Multicopy suppressor screens reveal convergent evolution of single-gene lysis proteins - Nature Chemical Biology

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