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Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription - Nature Chemical Biology

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Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription - Nature Chemical Biology

Tyrosine sulfation is a common posttranslational modification in mammals. To date, it has been thought to be limited to secreted and transmembrane proteins, but little is known about tyrosine sulfation on nuclear proteins. Here we report that SULT1B1 is a histone sulfotransferase that can sulfate the tyrosine 99 residue of nascent histone H3 in cytosol. The sulfated histone H3 can be transported into the nucleus and majorly deposited in the promoter regions of genes in chromatin.

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Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription - Nature Chemical Biology

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Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription - Nature Chemical Biology

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