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Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution - Nature Chemistry

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Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution - Nature Chemistry

The discovery of crosstalk effects on the renin–angiotensin system (RAS) is limited by the lack of approaches to quantitatively monitor, in real time, multiple components with subtle differences and short half-lives. Here we report a nanopore framework to quantitatively determine the effect of the hidden crosstalk between angiotensin-converting enzyme (ACE) and angiotensin-converting enzyme 2 (ACE2) on RAS.

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Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution - Nature Chemistry

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Protein nanopore reveals the renin–angiotensin system crosstalk with single-amino-acid resolution - Nature Chemistry

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