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Human PRPS1 filaments stabilize allosteric sites to regulate activity - Nature Structural & Molecular Biology

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Human PRPS1 filaments stabilize allosteric sites to regulate activity - Nature Structural & Molecular Biology

The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spectrum of diseases. Here we determine structures of human PRPS1 filaments in active and inhibited states, with fixed assembly contacts accommodating both conformations.

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Human PRPS1 filaments stabilize allosteric sites to regulate activity - Nature Structural & Molecular Biology

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Human PRPS1 filaments stabilize allosteric sites to regulate activity - Nature Structural & Molecular Biology

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