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Structural basis of paralog-specific KDM2A/B nucleosome recognition - Nature Chemical Biology

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Structural basis of paralog-specific KDM2A/B nucleosome recognition - Nature Chemical Biology

The nucleosome acidic patch is a major interaction hub for chromatin, providing a platform for enzymes to dock and orient for nucleosome-targeted activities. To define the molecular basis of acidic patch recognition proteome wide, we performed an amino acid resolution acidic patch interactome screen. We discovered that the histone H3 lysine 36 (H3K36) demethylase KDM2A, but not its closely related paralog, KDM2B, requires the acidic patch for nucleosome binding.

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Structural basis of paralog-specific KDM2A/B nucleosome recognition - Nature Chemical Biology

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Structural basis of paralog-specific KDM2A/B nucleosome recognition - Nature Chemical Biology

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