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Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants - Nature Biotechnology

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Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants - Nature Biotechnology

Most short sequences can be precisely written into a selected genomic target using prime editing; however, it remains unclear what factors govern insertion. We design a library of 3,604 sequences of various lengths and measure the frequency of their insertion into four genomic sites in three human cell lines, using different prime editor systems in varying DNA repair contexts. We

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Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants - Nature Biotechnology

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Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants - Nature Biotechnology

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