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Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy - Nature Microbiology

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Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy - Nature Microbiology

Type VI CRISPR systems protect against phage infection using the RNA-guided nuclease Cas13 to recognize viral messenger RNA. Upon target recognition, Cas13 cleaves phage and host transcripts non-specifically, leading to cell dormancy that is incompatible with phage propagation. However, whether and how infected cells recover from dormancy is unclear.

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Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy - Nature Microbiology

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Restriction endonuclease cleavage of phage DNA enables resuscitation from Cas13-induced bacterial dormancy - Nature Microbiology

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