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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis - Nature Communications

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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis - Nature Communications

Pyroptosis, a type of Gasdermin-mediated cell death, contributes to an exacerbation of inflammation. To test the hypothesis that GSDME-mediated pyroptosis aggravates the progression of atherosclerosis, we generate ApoE and GSDME dual deficiency mice. As compared with the control mice, GSDME−/−/ApoE−/− mice show a reduction of atherosclerotic lesion area and inflammatory response when induced with a high-fat diet.

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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis - Nature Communications

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GSDME-mediated pyroptosis promotes the progression and associated inflammation of atherosclerosis - Nature Communications

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