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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance - Nature Communications

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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance - Nature Communications

The failure of metabolic tissues to appropriately respond to insulin (“insulin resistance”) is an early marker in the pathogenesis of type 2 diabetes. Protein phosphorylation is central to the adipocyte insulin response, but how adipocyte signaling networks are dysregulated upon insulin resistance is unknown. Here we employ phosphoproteomics to delineate insulin signal transduction in adipocyte cells and adipose tissue.

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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance - Nature Communications

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Phosphoproteomics reveals rewiring of the insulin signaling network and multi-nodal defects in insulin resistance - Nature Communications

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