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Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice - Nature Medicine

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Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice - Nature Medicine

The most common form of genetic heart disease is hypertrophic cardiomyopathy (HCM), which is caused by variants in cardiac sarcomeric genes and leads to abnormal heart muscle thickening. Complications of HCM include heart failure, arrhythmia and sudden cardiac death. The dominant-negative c.1208G>A (p.R403Q) pathogenic variant (PV) in β-myosin (MYH7) is a common and well-studied PV that leads to increased cardiac contractility and HCM onset.

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Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice - Nature Medicine

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Base editing correction of hypertrophic cardiomyopathy in human cardiomyocytes and humanized mice - Nature Medicine

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