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Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration - Nature Aging

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Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration - Nature Aging

The commonalities and differences in cell-type-specific pathways that lead to Alzheimer disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single-nucleus transcriptome comparison of control, AD and PD striata. We describe three astrocyte subpopulations shared across different brain regions and evolutionarily conserved between humans and mice.

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Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration - Nature Aging

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Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration - Nature Aging

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