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Reducing affinity as a strategy to boost immunomodulatory antibody agonism - Nature

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Reducing affinity as a strategy to boost immunomodulatory antibody agonism - Nature

Antibody responses during infection and vaccination typically undergo affinity maturation to achieve high-affinity binding for efficient neutralization of pathogens1,2. Similarly, high affinity is routinely the goal for therapeutic antibody generation. However, in contrast to naturally occurring or direct-targeting therapeutic antibodies, immunomodulatory antibodies, which are designed to modulate receptor signalling, have not been widely examined for their affinity–function relationship.

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Reducing affinity as a strategy to boost immunomodulatory antibody agonism - Nature

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