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Perivascular signals drive microglial appetite - Nature Neuroscience

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Perivascular signals drive microglial appetite - Nature Neuroscience

Microglial synapse engulfment precedes brain amyloid plaque formation and probably contributes to early cognitive decline in Alzheimer's disease. The mechanisms that regulate microglia-mediated synapse engulfment are unclear. De Schepper et al. show that perivascular SPP1 induces microglia-mediated synapse engulfment, highlighting a neuroimmune interaction that contributes to synapse loss in amyloid pathology.

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Perivascular signals drive microglial appetite - Nature Neuroscience

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Perivascular signals drive microglial appetite - Nature Neuroscience

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