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IFNγ binding to extracellular matrix prevents fatal systemic toxicity - Nature Immunology

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IFNγ binding to extracellular matrix prevents fatal systemic toxicity - Nature Immunology

Interferon-γ (IFNγ) is an important mediator of cellular immune responses, but high systemic levels of this cytokine are associated with immunopathology. IFNγ binds to its receptor (IFNγR) and to extracellular matrix (ECM) via four positively charged C-terminal amino acids (KRKR), the ECM-binding domain (EBD). Across evolution, IFNγ is not well conserved, but the EBD is highly conserved, suggesting a critical function.

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IFNγ binding to extracellular matrix prevents fatal systemic toxicity - Nature Immunology

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IFNγ binding to extracellular matrix prevents fatal systemic toxicity - Nature Immunology

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