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Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid - Nature Protocols

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Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid - Nature Protocols

Misfolded alpha-synuclein (αSyn) aggregates are a hallmark event in Parkinson's disease (PD) and other synucleinopathies. Recently, αSyn seed amplification assays (αSyn-SAAs) have shown promise as a test for biochemical diagnosis of synucleinopathies. αSyn-SAAs use the intrinsic self-replicative nature of misfolded αSyn aggregates (seeds) to multiply them in vitro.

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Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid - Nature Protocols

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Seed amplification assay for the detection of pathologic alpha-synuclein aggregates in cerebrospinal fluid - Nature Protocols

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