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Towards a structurally resolved human protein interaction network - Nature Structural & Molecular Biology

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Towards a structurally resolved human protein interaction network - Nature Structural & Molecular Biology

Cellular functions are governed by molecular machines that assemble through protein-protein interactions. Their atomic details are critical to studying their molecular mechanisms. However, fewer than 5% of hundreds of thousands of human protein interactions have been structurally characterized. Here we test the potential and limitations of recent progress in deep-learning methods using AlphaFold2 to predict structures for 65,484 human protein interactions.

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Towards a structurally resolved human protein interaction network - Nature Structural & Molecular Biology

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Towards a structurally resolved human protein interaction network - Nature Structural & Molecular Biology

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