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Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis - Nature Metabolism

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Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis - Nature Metabolism

Oxidative stress modulates carcinogenesis in the liver; however, direct evidence for metabolic control of oxidative stress during pathogenesis, particularly, of progression from cirrhosis to hepatocellular carcinoma (HCC), has been lacking. Deficiency of transaldolase (TAL), a rate-limiting enzyme of the non-oxidative branch of the pentose phosphate pathway (PPP), restricts growth and predisposes to cirrhosis and HCC in mice and humans.

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Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis - Nature Metabolism

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Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis - Nature Metabolism

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