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Microglial cGAS–STING links innate immunity and Alzheimer's disease - Nature Aging

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Microglial cGAS–STING links innate immunity and Alzheimer's disease - Nature Aging

Neuroinflammation is increasingly recognized as an important pathological trigger for the development and progression of Alzheimer's disease. However, the molecular mechanism remains largely unclear. We identify activation of the neuroimmune cGAS–STING signaling pathway as a critical molecular link, predominantly in microglia, that contributes to Alzheimer's disease pathogenesis.

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Microglial cGAS–STING links innate immunity and Alzheimer's disease - Nature Aging

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Microglial cGAS–STING links innate immunity and Alzheimer's disease - Nature Aging

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