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ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation - Nature Cell Biology

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ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation - Nature Cell Biology

The EWS-FLI1 fusion oncoprotein deregulates transcription to initiate the paediatric cancer Ewing sarcoma. Here we used a domain-focused CRISPR screen to implicate the transcriptional repressor ETV6 as a unique dependency in this tumour. Using biochemical assays and epigenomics, we show that ETV6 competes with EWS-FLI1 for binding to select DNA elements enriched for short GGAA repeat sequences.

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ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation - Nature Cell Biology

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ETV6 dependency in Ewing sarcoma by antagonism of EWS-FLI1-mediated enhancer activation - Nature Cell Biology

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