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Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling - Nature Communications

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Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling - Nature Communications

Apical constriction is a cell shape change critical to vertebrate neural tube closure, and the contractile force required for this process is generated by actin-myosin networks. The signaling cue that instructs this process has remained elusive. Here, we identify Wnt4 and the transmembrane ephrinB2 protein as playing an instructive role in neural tube closure as members of a signaling complex we termed WERDS (Wnt4, EphrinB2, Ror2, Dishevelled (Dsh2), and Shroom3).

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Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling - Nature Communications

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Wnt4 and ephrinB2 instruct apical constriction via Dishevelled and non-canonical signaling - Nature Communications

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