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Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition - Nature Structural & Molecular Biology

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Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition - Nature Structural & Molecular Biology

Poly(A)-tail-mediated post-transcriptional regulation of maternal mRNAs is vital in the oocyte-to-embryo transition (OET). Nothing is known about poly(A) tail dynamics during the human OET. Here, we show that poly(A) tail length and internal non-A residues are highly dynamic during the human OET, using poly(A)-inclusive RNA isoform sequencing (PAIso-seq).

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Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition - Nature Structural & Molecular Biology

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Remodeling of maternal mRNA through poly(A) tail orchestrates human oocyte-to-embryo transition - Nature Structural & Molecular Biology

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