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CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization - Nature Chemical Biology

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CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization - Nature Chemical Biology

The production efficiency of microbial cell factories is sometimes limited by the lack of effective methods to regulate multiple targets in a coordinated manner. Here taking the biosynthesis of glucosamine-6-phosphate (GlcN6P) in Bacillus subtilis as an example, a 'design–build–test–learn' framework was proposed to achieve efficient multiplexed optimization of metabolic pathways. A platform strain was built to carry biosensor signal-amplifying circuits and two genetic regulation circuits.

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CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization - Nature Chemical Biology

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CRISPR–dCas12a-mediated genetic circuit cascades for multiplexed pathway optimization - Nature Chemical Biology

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