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The role of G protein conformation in receptor–G protein selectivity - Nature Chemical Biology

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The role of G protein conformation in receptor–G protein selectivity - Nature Chemical Biology

G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear. Structural studies emphasize structural complementarity of GPCRs and nucleotide-free G proteins, but selectivity is likely to be determined by transient intermediate-state complexes that exist before nucleotide release.

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The role of G protein conformation in receptor–G protein selectivity - Nature Chemical Biology

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The role of G protein conformation in receptor–G protein selectivity - Nature Chemical Biology

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