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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis - Cell Death & Differentiation

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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis - Cell Death & Differentiation

Kinase signaling in the tiered activation of inflammasomes and associated pyroptosis is a prime therapeutic target for inflammatory diseases. While MAPKs subsume pivotal roles during inflammasome priming, specifically the MAP3K7/JNK1/NLRP3 licensing axis, their involvement in successive steps of inflammasome activation is poorly defined. Using live-cell MAPK biosensors to focus on the inflammasome triggering event allowed us to identify a subsequent process of biphasic JNK activation. We

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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis - Cell Death & Differentiation

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Biphasic JNK signaling reveals distinct MAP3K complexes licensing inflammasome formation and pyroptosis - Cell Death & Differentiation

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for Humanity's Progress