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CXCR5+PD-1++ CD4+ T cells colonize infant intestines early in life and promote B cell maturation - Cellular & Molecular Immunology
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Gastrointestinal infections are a major cause for serious clinical complications in infants. The induction of antibody responses by B cells is critical for protective immunity against infections and requires CXCR5+PD-1++ CD4+ T cells (TFH cells). We investigated the ontogeny of CXCR5+PD-1++ CD4+ T cells in human intestines.
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