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HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly - Nature Structural & Molecular Biology

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HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly - Nature Structural & Molecular Biology

HIV-1 Gag metamorphoses inside each virion, from an immature lattice that forms during viral production to a mature capsid that drives infection. Here we show that the immature lattice is required to concentrate the cellular metabolite inositol hexakisphosphate (IP6) into virions to catalyze mature capsid assembly. Disabling the ability of HIV-1 to enrich IP6 does not prevent immature lattice formation or production of the virus.

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HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly - Nature Structural & Molecular Biology

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HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly - Nature Structural & Molecular Biology

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