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Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages - Nature Cell Biology

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Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages - Nature Cell Biology

In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactivation (XCI). Although Polycomb repressive complex (PRC) 1 and PRC2 have both been implicated in gene silencing, their exact roles in XCI during in vivo development have remained elusive. To this end, we have studied mouse embryos lacking either PRC1 or PRC2.

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Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages - Nature Cell Biology

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Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages - Nature Cell Biology

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