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Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123 - Nature Biotechnology

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Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123 - Nature Biotechnology

CD123, the alpha chain of the IL-3 receptor, is an attractive target for acute myeloid leukemia (AML) treatment. However, cytotoxic antibodies or T cell engagers targeting CD123 had insufficient efficacy or safety in clinical trials. We show that expression of CD64, the high-affinity receptor for human IgG, on AML blasts confers resistance to anti-CD123 antibody-dependent cell cytotoxicity (ADCC) in vitro.

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Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123 - Nature Biotechnology

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Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123 - Nature Biotechnology

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