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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse - Nature Immunology

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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse - Nature Immunology

The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced understanding of the characteristics of the IS and its formation processes, the mechanisms that regulate its stability via the cytoskeleton are unclear. Here, we show that Nogo receptor 1 (NgR1) has an important function in modulating NK cell-mediated killing by destabilization of IS formation.

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receptor cell synapse health cell biology biology microbiology

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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse - Nature Immunology

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NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse - Nature Immunology

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