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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases - Nature Genetics

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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases - Nature Genetics

Metabolic processes can influence disease risk and provide therapeutic targets. By conducting genome-wide association studies of 1,091 blood metabolites and 309 metabolite ratios, we identified associations with 690 metabolites at 248 loci and associations with 143 metabolite ratios at 69 loci. Integrating metabolite-gene and gene expression information identified 94 effector genes for 109 metabolites and 48 metabolite ratios.

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metabolites genetic diseases science biology genetics

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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases - Nature Genetics

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Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases - Nature Genetics

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